science wire

Sirtuin 1 at the pinnacle of metabolic control
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+? (Review) Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD+-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans.

New insightes in early specification of pancreas progenitors
RNA profiling and ChIP-Sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.

Thalamic control of cortical states
The group of Carl Petersen (LSENS - Laboratoire de traitement sensoriel ) investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse.

Transcriptional barcoding of retinal cells identifies disease target cells
Transcriptional barcoding of retinal cells identifies disease target cells By developing a large scale gene expression map for retinal cell types, FMI Neurobiologists have been able to identify the cells in the retina, where the genes causing retinal diseases specifically act. This narrows down the search for a better understanding of the diseases and opens up new avenues for therapeutic approaches.

Roche medicine Avastin receives EU approval for the treatment of women with newly diagnosed, advanced ovarian cancer
Roche medicine Avastin receives EU approval for the treatment of women with newly diagnosed, advanced ovarian cancer Avastin represents first major treatment advance for women with ovarian canc